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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d221452ec92b4195e6726bd777bc73d5d3be7770d975e5afce944d5afa6fbc5' 
  AND token = 'U7Q+/eryVBrL1/y+ogmxVAcLJugWrheZ69+OwwzeS/Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}